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CONCLUSIONS This study suggests that initiating cigarette smoking early during adolescence is associated with reductions in HRQOL in later adulthood

Inflammation and cancer Many cancers arise in areas of chronic inflammation, which plays a major role in tumor invasion, progression, and metastasis, largely through the cytokine-mediated activation of mechanisms involved in tissue repair, cell proliferation and angiogenesis [20, 22, 51,52,53]

These are all very well established, all well studied

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